Drug interactions
Fish oil + Reteplase
Severity: Moderate
Fish oil and Reteplase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic with substantial bleeding risk, and omega-3 fatty acids mildly impair platelet function. The additional effect of fish oil is likely small but may contribute to bleeding.
What this interaction means in plain words
Fish oil and Reteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis from fibrinolysis and mild platelet inhibition.
What to do
Monitor closely for bleeding during and after thrombolysis; fish oil supplements can generally be held in the acute setting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fish oil
- Antithrombin alfa + Fish oil Moderate
- Antithrombin iii + Fish oil Moderate
- Aspirin / citric acid / sodium bicarbonate + Fish oil Moderate
- Aspirin + Fish oil Moderate
- Betrixaban + Fish oil Moderate
- Bivalirudin + Fish oil Moderate
Frequently asked questions
Can I take Fish oil with Reteplase?
MediHelp rates the interaction as moderate. Fish oil and Reteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reteplase is a thrombolytic with substantial bleeding risk, and omega-3 fatty acids mildly impair platelet function. The additional effect of fish oil is likely small but may contribute to bleeding.
How serious is the interaction between Fish oil and Reteplase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding during and after thrombolysis; fish oil supplements can generally be held in the acute setting.
What other medicines interact with Fish oil?
MediHelp also lists interactions of Fish oil with, for example, Antithrombin alfa, Antithrombin iii, Aspirin / citric acid / sodium bicarbonate. The full list is on the Fish oil page.
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