Drug interactions
Fish oil triglycerides + Ibuprofen
Severity: Moderate
Fish oil triglycerides and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids at prescription doses can modestly impair platelet aggregation and prolong bleeding time. Combined with ibuprofen, which inhibits platelet function and irritates the gastric mucosa, the tendency to bleed may increase.
What this interaction means in plain words
Fish oil triglycerides and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on platelet function and hemostasis.
What to do
Monitor for signs of bleeding, especially GI bleeding, when high-dose fish oil is used with regular ibuprofen. Reassess the need for either agent in patients who also take anticoagulants or other antiplatelets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Fish oil triglycerides with Ibuprofen?
MediHelp rates the interaction as moderate. Fish oil triglycerides and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omega-3 fatty acids at prescription doses can modestly impair platelet aggregation and prolong bleeding time. Combined with ibuprofen, which inhibits platelet function and irritates the gastric mucosa, the tendency to bleed may increase.
How serious is the interaction between Fish oil triglycerides and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, especially GI bleeding, when high-dose fish oil is used with regular ibuprofen. Reassess the need for either agent in patients who also take anticoagulants or other antiplatelets.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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