Drug interactions
Fish oil triglycerides + Meclofenamic acid
Severity: Moderate
Fish oil triglycerides and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids have mild antiplatelet effects and may prolong bleeding time. Combined with an NSAID, which also impairs platelet function and can cause gastrointestinal lesions, the bleeding risk may be modestly increased.
What this interaction means in plain words
Fish oil triglycerides and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet inhibition: omega-3 fatty acids alter platelet eicosanoid production while the NSAID inhibits COX-1.
What to do
Monitor for bleeding or bruising, particularly with prolonged use or higher omega-3 doses. Consider gastroprotection in patients at risk of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Fish oil triglycerides with Meclofenamic acid?
MediHelp rates the interaction as moderate. Fish oil triglycerides and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose omega-3 fatty acids have mild antiplatelet effects and may prolong bleeding time. Combined with an NSAID, which also impairs platelet function and can cause gastrointestinal lesions, the bleeding risk may be modestly increased.
How serious is the interaction between Fish oil triglycerides and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding or bruising, particularly with prolonged use or higher omega-3 doses. Consider gastroprotection in patients at risk of GI bleeding.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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