Drug interactions
Fish oil triglycerides + Tolmetin
Severity: Moderate
Fish oil triglycerides and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids have mild antiplatelet effects and may prolong bleeding time. With an NSAID that also impairs platelet function and irritates the gut, bleeding risk may increase slightly.
What this interaction means in plain words
Fish oil triglycerides and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects of omega-3 fatty acids and NSAID COX inhibition.
What to do
Monitor for signs of bleeding, particularly in patients with a history of gastrointestinal bleeding or on other antithrombotics. Review ongoing need for the NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Fish oil triglycerides with Tolmetin?
MediHelp rates the interaction as moderate. Fish oil triglycerides and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose omega-3 fatty acids have mild antiplatelet effects and may prolong bleeding time. With an NSAID that also impairs platelet function and irritates the gut, bleeding risk may increase slightly.
How serious is the interaction between Fish oil triglycerides and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly in patients with a history of gastrointestinal bleeding or on other antithrombotics. Review ongoing need for the NSAID.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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