Drug interactions
Flecainide + Pimozide
Severity: Contraindicated
Flecainide and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide markedly prolongs the QT interval and carries a risk of torsades de pointes, and flecainide adds proarrhythmic effects. The combination can cause life-threatening ventricular arrhythmias.
What this interaction means in plain words
Flecainide and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flecainide belongs to Cardiovascular; Pimozide belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Do not use together; choose an alternative antipsychotic or antiarrhythmic with no QT effect.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
- Flecainide + Vandetanib Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Flecainide with Pimozide?
MediHelp rates the interaction as contraindicated. Flecainide and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide markedly prolongs the QT interval and carries a risk of torsades de pointes, and flecainide adds proarrhythmic effects. The combination can cause life-threatening ventricular arrhythmias.
How serious is the interaction between Flecainide and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative antipsychotic or antiarrhythmic with no QT effect.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Ritonavir. The full list is on the Flecainide page.
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