Drug interactions
Flecainide + Tipranavir
Severity: Contraindicated
Flecainide and Tipranavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which inhibits CYP2D6 and CYP3A4 and raises flecainide levels. This can cause QRS and QT prolongation and serious ventricular arrhythmias. Labeling contraindicates ritonavir-boosted tipranavir with flecainide.
What this interaction means in plain words
Flecainide and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flecainide belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted inhibition of CYP2D6 reduces flecainide metabolism, increasing exposure.
What to do
Do not co-administer; choose another antiarrhythmic or antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Vandetanib Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Tipranavir?
MediHelp rates the interaction as contraindicated. Flecainide and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir is given with ritonavir, which inhibits CYP2D6 and CYP3A4 and raises flecainide levels. This can cause QRS and QT prolongation and serious ventricular arrhythmias. Labeling contraindicates ritonavir-boosted tipranavir with flecainide.
How serious is the interaction between Flecainide and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose another antiarrhythmic or antiretroviral regimen.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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