Drug interactions
Fleroxacin + Foscarnet
Severity: Moderate
Fleroxacin and Foscarnet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet can cause seizures, partly through lowering ionized calcium and magnesium. Fluoroquinolones such as fleroxacin also lower the seizure threshold, so concurrent use may raise seizure risk.
What this interaction means in plain words
Fleroxacin and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive lowering of seizure threshold; the exact mechanism of interaction is not established.
What to do
Monitor calcium, magnesium and potassium and correct abnormalities. Consider a different antibacterial in patients with seizure history or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Fleroxacin with Foscarnet?
MediHelp rates the interaction as moderate. Fleroxacin and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet can cause seizures, partly through lowering ionized calcium and magnesium. Fluoroquinolones such as fleroxacin also lower the seizure threshold, so concurrent use may raise seizure risk.
How serious is the interaction between Fleroxacin and Foscarnet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor calcium, magnesium and potassium and correct abnormalities. Consider a different antibacterial in patients with seizure history or renal impairment.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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