Drug interactions
Fleroxacin + Gliclazide
Severity: Moderate
Fleroxacin and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients on sulfonylureas, with severe hypoglycemia reported. Older adults and those with renal impairment are at higher risk.
What this interaction means in plain words
Fleroxacin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones block pancreatic potassium channels and stimulate insulin release, adding to the sulfonylurea effect.
What to do
Monitor blood glucose closely during fluoroquinolone therapy and advise patients to report symptoms; consider another antibiotic class in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Fleroxacin with Gliclazide?
MediHelp rates the interaction as moderate. Fleroxacin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients on sulfonylureas, with severe hypoglycemia reported. Older adults and those with renal impairment are at higher risk.
How serious is the interaction between Fleroxacin and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during fluoroquinolone therapy and advise patients to report symptoms; consider another antibiotic class in high-risk patients.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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