Drug interactions
Fleroxacin + Glipizide-metformin
Severity: Moderate
Fleroxacin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, with the greatest risk in older patients and those with renal impairment. The risk is highest with sulfonylureas.
What this interaction means in plain words
Fleroxacin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones affect pancreatic beta-cell potassium channels, increasing insulin release and causing dysglycemia in combination with sulfonylureas.
What to do
Monitor blood glucose during therapy and educate patients to recognize hypoglycemia. Stop the quinolone and consider an alternative antibiotic if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Fleroxacin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Fleroxacin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, with the greatest risk in older patients and those with renal impairment. The risk is highest with sulfonylureas.
How serious is the interaction between Fleroxacin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during therapy and educate patients to recognize hypoglycemia. Stop the quinolone and consider an alternative antibiotic if significant dysglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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