Drug interactions
Fleroxacin + Insulin glargine-lixisenatide
Severity: Moderate
Fleroxacin and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving insulin or other antidiabetic drugs. Severe, occasionally fatal, hypoglycemia has been described, mainly in older patients and those with renal impairment.
What this interaction means in plain words
Fleroxacin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinolones stimulate pancreatic insulin release by blocking beta-cell ATP-sensitive potassium channels, adding to insulin effects.
What to do
Monitor blood glucose closely during the quinolone course and adjust insulin as needed. Counsel patients on symptoms of hypoglycemia and switch to a non-quinolone antibiotic if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Fleroxacin with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Fleroxacin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving insulin or other antidiabetic drugs. Severe, occasionally fatal, hypoglycemia has been described, mainly in older patients and those with renal impairment.
How serious is the interaction between Fleroxacin and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the quinolone course and adjust insulin as needed. Counsel patients on symptoms of hypoglycemia and switch to a non-quinolone antibiotic if dysglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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