Drug interactions
Fleroxacin + Iron
Severity: Moderate
Fleroxacin and Iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron chelates fluoroquinolones such as fleroxacin, decreasing their absorption and possibly causing subtherapeutic antibiotic levels.
What this interaction means in plain words
Fleroxacin and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of the quinolone by iron in the gastrointestinal tract, reducing absorption.
What to do
Take fleroxacin at least 2 hours before or several hours after oral iron. Use intravenous iron if separation is not possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Frequently asked questions
Can I take Fleroxacin with Iron?
MediHelp rates the interaction as moderate. Fleroxacin and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron chelates fluoroquinolones such as fleroxacin, decreasing their absorption and possibly causing subtherapeutic antibiotic levels.
How serious is the interaction between Fleroxacin and Iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take fleroxacin at least 2 hours before or several hours after oral iron. Use intravenous iron if separation is not possible.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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