Drug interactions
Baloxavir marboxil + Iron
Severity: Moderate
Baloxavir marboxil and Iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Polyvalent cations such as iron can bind baloxavir in the gut and lower its absorption, which may reduce antiviral effect. Supporting data come mainly from animal work and labeling advice.
What this interaction means in plain words
Baloxavir marboxil and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baloxavir marboxil belongs to Anti Virals; Iron belongs to Gastrointestinal Tract.
Why it happens
Chelation of baloxavir by iron in the gastrointestinal tract, decreasing absorption.
What to do
Avoid taking oral iron products at the same time as baloxavir; separate dosing where possible. Intravenous iron is not expected to interact this way.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
- Carbidopa + Iron Moderate
Other interactions of Baloxavir marboxil
- Aluminum hydroxide + Baloxavir marboxil Moderate
- Baloxavir marboxil + Calcium Moderate
- Baloxavir marboxil + Calcium carbonate Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Baloxavir marboxil + Ferrous fumarate Moderate
- Baloxavir marboxil + Ferrous gluconate Moderate
Frequently asked questions
Can I take Baloxavir marboxil with Iron?
MediHelp rates the interaction as moderate. Baloxavir marboxil and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Polyvalent cations such as iron can bind baloxavir in the gut and lower its absorption, which may reduce antiviral effect. Supporting data come mainly from animal work and labeling advice.
How serious is the interaction between Baloxavir marboxil and Iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking oral iron products at the same time as baloxavir; separate dosing where possible. Intravenous iron is not expected to interact this way.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Calcium acetate. The full list is on the Iron page.
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