Drug interactions
Fleroxacin + Metformin-repaglinide
Severity: Moderate
Fleroxacin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients taking antidiabetic drugs. The risk is greatest with insulin secretagogues such as repaglinide and in older patients or those with renal impairment.
What this interaction means in plain words
Fleroxacin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinolone effects on pancreatic beta-cell insulin release cause dysglycemia and add to the antidiabetic drugs' effects.
What to do
Monitor blood glucose during the quinolone course and counsel the patient on symptoms of hypoglycemia. Stop the quinolone and treat if marked dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Fleroxacin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Fleroxacin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, particularly in patients taking antidiabetic drugs. The risk is greatest with insulin secretagogues such as repaglinide and in older patients or those with renal impairment.
How serious is the interaction between Fleroxacin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the quinolone course and counsel the patient on symptoms of hypoglycemia. Stop the quinolone and treat if marked dysglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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