Drug interactions
Fleroxacin + Nateglinide
Severity: Moderate
Fleroxacin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in patients taking antidiabetic drugs. Combined with an insulin secretagogue like nateglinide, severe hypoglycemia may occur, particularly in older patients or those with renal impairment.
What this interaction means in plain words
Fleroxacin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolone effects on pancreatic beta-cell insulin release add to nateglinide's insulin secretagogue action.
What to do
Monitor blood glucose closely during fluoroquinolone therapy. Counsel the patient on hypoglycemia symptoms and stop the quinolone if glucose becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Fleroxacin with Nateglinide?
MediHelp rates the interaction as moderate. Fleroxacin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in patients taking antidiabetic drugs. Combined with an insulin secretagogue like nateglinide, severe hypoglycemia may occur, particularly in older patients or those with renal impairment.
How serious is the interaction between Fleroxacin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during fluoroquinolone therapy. Counsel the patient on hypoglycemia symptoms and stop the quinolone if glucose becomes unstable.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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