Drug interactions
Fludrocortisone + Human papillomavirus vaccine nonavalent
Severity: Minor
Fludrocortisone and Human papillomavirus vaccine nonavalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at supraphysiologic doses can reduce vaccine immune responses. At the usual replacement doses of fludrocortisone, which is mostly mineralocorticoid, the effect on the response to this non-live vaccine is expected to be negligible.
What this interaction means in plain words
Fludrocortisone and Human papillomavirus vaccine nonavalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression from corticosteroids may blunt the antibody response, but only at higher glucocorticoid-equivalent doses.
What to do
Vaccinate on schedule; the vaccine is non-live and fludrocortisone replacement doses do not need to be stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Human papillomavirus vaccine nonavalent?
MediHelp rates the interaction as minor. Fludrocortisone and Human papillomavirus vaccine nonavalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids at supraphysiologic doses can reduce vaccine immune responses. At the usual replacement doses of fludrocortisone, which is mostly mineralocorticoid, the effect on the response to this non-live vaccine is expected to be negligible.
How serious is the interaction between Fludrocortisone and Human papillomavirus vaccine nonavalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule; the vaccine is non-live and fludrocortisone replacement doses do not need to be stopped.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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