Drug interactions
Fludrocortisone + Hydrochlorothiazide-olmesartan
Severity: Moderate
Fludrocortisone and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity and, with hydrochlorothiazide, can cause substantial potassium loss. Hypokalemia may provoke arrhythmias and muscle weakness.
What this interaction means in plain words
Fludrocortisone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive renal potassium excretion from mineralocorticoid effect and thiazide action.
What to do
Monitor serum potassium regularly and supplement as needed. Reassess the need for the thiazide if hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Fludrocortisone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid activity and, with hydrochlorothiazide, can cause substantial potassium loss. Hypokalemia may provoke arrhythmias and muscle weakness.
How serious is the interaction between Fludrocortisone and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and supplement as needed. Reassess the need for the thiazide if hypokalemia persists.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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