Drug interactions
Fludrocortisone + Hydrocortisone
Severity: Minor
Fludrocortisone and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These are both corticosteroids and are commonly used together deliberately as replacement therapy in adrenal insufficiency. Their mineralocorticoid and glucocorticoid effects are additive, and no meaningful pharmacokinetic interaction is established.
What this interaction means in plain words
Fludrocortisone and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Additive corticosteroid pharmacodynamic effects; no established pharmacokinetic interaction.
What to do
Titrate doses to blood pressure, electrolytes and clinical status, and monitor potassium and fluid balance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Hydrocortisone?
MediHelp rates the interaction as minor. Fludrocortisone and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. These are both corticosteroids and are commonly used together deliberately as replacement therapy in adrenal insufficiency. Their mineralocorticoid and glucocorticoid effects are additive, and no meaningful pharmacokinetic interaction is established.
How serious is the interaction between Fludrocortisone and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses to blood pressure, electrolytes and clinical status, and monitor potassium and fluid balance.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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