Drug interactions
Fludrocortisone + Indapamide
Severity: Moderate
Fludrocortisone and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity and promotes potassium excretion, which adds to indapamide-induced potassium loss. Significant hypokalemia may result.
What this interaction means in plain words
Fludrocortisone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting through mineralocorticoid action and thiazide-like diuresis.
What to do
Monitor serum potassium regularly and replace potassium or adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Indapamide?
MediHelp rates the interaction as moderate. Fludrocortisone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid activity and promotes potassium excretion, which adds to indapamide-induced potassium loss. Significant hypokalemia may result.
How serious is the interaction between Fludrocortisone and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and replace potassium or adjust doses as needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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