Drug interactions
Fludrocortisone + Indinavir
Severity: Moderate
Fludrocortisone and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir may increase fludrocortisone exposure and enhance mineralocorticoid effects such as sodium retention, edema, hypertension and hypokalemia.
What this interaction means in plain words
Fludrocortisone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4 and P-glycoprotein, reducing the clearance of fludrocortisone.
What to do
Monitor blood pressure, serum potassium and fluid status, and reduce the fludrocortisone dose if excess effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fludrocortisone and Indinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Indinavir?
MediHelp rates the interaction as moderate. Fludrocortisone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir may increase fludrocortisone exposure and enhance mineralocorticoid effects such as sodium retention, edema, hypertension and hypokalemia.
How serious is the interaction between Fludrocortisone and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and fluid status, and reduce the fludrocortisone dose if excess effects appear.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
