Drug interactions
Fludrocortisone + Insulin degludec / insulin aspart
Severity: Moderate
Fludrocortisone and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has some glucocorticoid activity and can raise blood glucose, which may reduce the effect of insulin. Patients with diabetes may need higher insulin doses.
What this interaction means in plain words
Fludrocortisone and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid effects increase hepatic gluconeogenesis and insulin resistance, opposing insulin action.
What to do
Monitor blood glucose more often when fludrocortisone is started, changed or stopped, and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Fludrocortisone and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has some glucocorticoid activity and can raise blood glucose, which may reduce the effect of insulin. Patients with diabetes may need higher insulin doses.
How serious is the interaction between Fludrocortisone and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when fludrocortisone is started, changed or stopped, and adjust the insulin dose as needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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