Drug interactions
Fludrocortisone + Ketorolac intranasal
Severity: Moderate
Fludrocortisone and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastrointestinal irritation, ulceration and bleeding. Intranasal ketorolac gives lower systemic exposure than oral or injected forms, but absorption is still sufficient to carry some risk.
What this interaction means in plain words
Fludrocortisone and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects on mucosal defense.
What to do
Limit the duration of ketorolac and watch for GI bleeding; consider gastroprotection in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Fludrocortisone and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastrointestinal irritation, ulceration and bleeding. Intranasal ketorolac gives lower systemic exposure than oral or injected forms, but absorption is still sufficient to carry some risk.
How serious is the interaction between Fludrocortisone and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of ketorolac and watch for GI bleeding; consider gastroprotection in patients with additional risk factors.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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