Drug interactions
Fludrocortisone + Lumefantrine
Severity: Minor
Fludrocortisone and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 substrates, but no clinically meaningful interaction is established. Any effect on lumefantrine exposure from fludrocortisone is theoretical.
What this interaction means in plain words
Fludrocortisone and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical CYP3A4 competition or weak induction; not clinically established.
What to do
No dose change is needed; monitor the clinical response to antimalarial treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Lumefantrine?
MediHelp rates the interaction as minor. Fludrocortisone and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are CYP3A4 substrates, but no clinically meaningful interaction is established. Any effect on lumefantrine exposure from fludrocortisone is theoretical.
How serious is the interaction between Fludrocortisone and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor the clinical response to antimalarial treatment.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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