Drug interactions
Fludrocortisone + Meclofenamate
Severity: Moderate
Fludrocortisone and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID raises the risk of gastric irritation, ulceration and bleeding. NSAIDs can also cause sodium and fluid retention, adding to the mineralocorticoid effect of fludrocortisone and potentially worsening hypertension or edema.
What this interaction means in plain words
Fludrocortisone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury, plus additive sodium and fluid retention.
What to do
Use the lowest effective NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor blood pressure, edema and GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Meclofenamate?
MediHelp rates the interaction as moderate. Fludrocortisone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID raises the risk of gastric irritation, ulceration and bleeding. NSAIDs can also cause sodium and fluid retention, adding to the mineralocorticoid effect of fludrocortisone and potentially worsening hypertension or edema.
How serious is the interaction between Fludrocortisone and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor blood pressure, edema and GI bleeding symptoms.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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