Drug interactions
Fludrocortisone + Metformin
Severity: Minor
Fludrocortisone and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has some glucocorticoid activity that can raise blood glucose. This may slightly reduce the glucose-lowering effect of metformin.
What this interaction means in plain words
Fludrocortisone and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as corticosteroid glucocorticoid activity increases hepatic glucose output and insulin resistance.
What to do
Monitor blood glucose when fludrocortisone is started or changed, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Metformin
Frequently asked questions
Can I take Fludrocortisone with Metformin?
MediHelp rates the interaction as minor. Fludrocortisone and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone has some glucocorticoid activity that can raise blood glucose. This may slightly reduce the glucose-lowering effect of metformin.
How serious is the interaction between Fludrocortisone and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fludrocortisone is started or changed, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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