Drug interactions
Fludrocortisone + Nefazodone
Severity: Moderate
Fludrocortisone and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and may raise fludrocortisone exposure, increasing mineralocorticoid effects such as fluid retention, hypertension and hypokalemia. The clinical effect is likely modest at replacement doses.
What this interaction means in plain words
Fludrocortisone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4-mediated metabolism of fludrocortisone.
What to do
Monitor blood pressure, edema and serum potassium, and reduce the fludrocortisone dose if excess mineralocorticoid effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Nefazodone?
MediHelp rates the interaction as moderate. Fludrocortisone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a potent CYP3A4 inhibitor and may raise fludrocortisone exposure, increasing mineralocorticoid effects such as fluid retention, hypertension and hypokalemia. The clinical effect is likely modest at replacement doses.
How serious is the interaction between Fludrocortisone and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium, and reduce the fludrocortisone dose if excess mineralocorticoid effects appear.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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