Drug interactions
Fludrocortisone + Olodaterol inhaled
Severity: Moderate
Fludrocortisone and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium. Together they can lead to clinically relevant hypokalemia, which raises the risk of arrhythmia, particularly in patients with cardiac disease or other potassium-lowering drugs.
What this interaction means in plain words
Fludrocortisone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from mineralocorticoid-induced renal potassium loss and beta2-agonist-driven intracellular potassium shift.
What to do
Monitor serum potassium periodically and replace potassium as needed, especially in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Fludrocortisone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium. Together they can lead to clinically relevant hypokalemia, which raises the risk of arrhythmia, particularly in patients with cardiac disease or other potassium-lowering drugs.
How serious is the interaction between Fludrocortisone and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace potassium as needed, especially in patients with cardiac risk factors.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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