Drug interactions
Fludrocortisone + Oxymetholone
Severity: Minor
Fludrocortisone and Oxymetholone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both fludrocortisone, a mineralocorticoid, and oxymetholone, an anabolic androgen, promote sodium and water retention. Used together they may produce additive fluid retention and edema, which can be important in patients with heart failure, hypertension or renal disease.
What this interaction means in plain words
Fludrocortisone and Oxymetholone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic sodium and fluid retention from mineralocorticoid and androgenic effects.
What to do
Monitor body weight, edema and blood pressure, particularly in patients with cardiac or renal impairment. Reduce the dose of one agent or add diuretic therapy if clinically significant fluid retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Oxymetholone?
MediHelp rates the interaction as minor. Fludrocortisone and Oxymetholone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both fludrocortisone, a mineralocorticoid, and oxymetholone, an anabolic androgen, promote sodium and water retention. Used together they may produce additive fluid retention and edema, which can be important in patients with heart failure, hypertension or renal disease.
How serious is the interaction between Fludrocortisone and Oxymetholone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor body weight, edema and blood pressure, particularly in patients with cardiac or renal impairment. Reduce the dose of one agent or add diuretic therapy if clinically significant fluid retention develops.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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