Drug interactions
Fludrocortisone + Parecoxib
Severity: Moderate
Fludrocortisone and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, a COX-2 inhibitor, combined with a corticosteroid can increase the risk of GI ulceration and bleeding, though the risk is lower than with nonselective NSAIDs. NSAID-related fluid retention may also add to fludrocortisone's sodium-retaining effect, worsening hypertension or edema.
What this interaction means in plain words
Fludrocortisone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury and additive sodium and fluid retention.
What to do
Use the shortest possible course at the lowest dose and consider gastroprotection in high-risk patients. Monitor blood pressure, edema and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Parecoxib?
MediHelp rates the interaction as moderate. Fludrocortisone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, a COX-2 inhibitor, combined with a corticosteroid can increase the risk of GI ulceration and bleeding, though the risk is lower than with nonselective NSAIDs. NSAID-related fluid retention may also add to fludrocortisone's sodium-retaining effect, worsening hypertension or edema.
How serious is the interaction between Fludrocortisone and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest possible course at the lowest dose and consider gastroprotection in high-risk patients. Monitor blood pressure, edema and signs of GI bleeding.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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