Drug interactions
Fludrocortisone + Phenindione
Severity: Moderate
Fludrocortisone and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter the anticoagulant response in unpredictable directions and may also increase bleeding risk by affecting the gastrointestinal mucosa and vascular integrity. Fludrocortisone has little glucocorticoid activity, so the effect is likely modest.
What this interaction means in plain words
Fludrocortisone and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic effects on coagulation and vascular integrity; the mechanism is not well established.
What to do
Monitor INR more frequently when starting, stopping or changing the fludrocortisone dose, and adjust phenindione accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Phenindione?
MediHelp rates the interaction as moderate. Fludrocortisone and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter the anticoagulant response in unpredictable directions and may also increase bleeding risk by affecting the gastrointestinal mucosa and vascular integrity. Fludrocortisone has little glucocorticoid activity, so the effect is likely modest.
How serious is the interaction between Fludrocortisone and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when starting, stopping or changing the fludrocortisone dose, and adjust phenindione accordingly.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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