Drug interactions
Fludrocortisone + Pimozide
Severity: Moderate
Fludrocortisone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone can cause hypokalemia and hypomagnesemia, which increase the risk of torsades de pointes with QT-prolonging pimozide. Any effect on CYP3A4 is minimal.
What this interaction means in plain words
Fludrocortisone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Pimozide belongs to Central Nervous System.
Why it happens
Mineralocorticoid-induced potassium loss potentiates pimozide QT prolongation.
What to do
Monitor serum potassium and magnesium and correct deficits; obtain an ECG if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Pimozide?
MediHelp rates the interaction as moderate. Fludrocortisone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone can cause hypokalemia and hypomagnesemia, which increase the risk of torsades de pointes with QT-prolonging pimozide. Any effect on CYP3A4 is minimal.
How serious is the interaction between Fludrocortisone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits; obtain an ECG if risk factors are present.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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