Drug interactions
Fludrocortisone + Salicylates
Severity: Moderate
Fludrocortisone and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with a salicylate increases the risk of GI irritation, ulceration and bleeding. Corticosteroids can also lower salicylate levels, and salicylate levels may rise when the steroid is withdrawn.
What this interaction means in plain words
Fludrocortisone and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury, and corticosteroid-increased salicylate clearance.
What to do
Consider gastroprotection in at-risk patients and monitor for GI bleeding. Watch salicylate response when fludrocortisone is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Salicylates?
MediHelp rates the interaction as moderate. Fludrocortisone and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with a salicylate increases the risk of GI irritation, ulceration and bleeding. Corticosteroids can also lower salicylate levels, and salicylate levels may rise when the steroid is withdrawn.
How serious is the interaction between Fludrocortisone and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection in at-risk patients and monitor for GI bleeding. Watch salicylate response when fludrocortisone is started or stopped.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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