Drug interactions
Fludrocortisone + Salsalate
Severity: Moderate
Fludrocortisone and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID, and combining it with a corticosteroid increases the risk of gastrointestinal irritation and ulceration. Fluid retention from fludrocortisone may also offset the NSAID's benefit in patients with hypertension or edema.
What this interaction means in plain words
Fludrocortisone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury and sodium retention.
What to do
Use the lowest effective salsalate dose and consider gastroprotection in high-risk patients. Monitor blood pressure, edema and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Salsalate?
MediHelp rates the interaction as moderate. Fludrocortisone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID, and combining it with a corticosteroid increases the risk of gastrointestinal irritation and ulceration. Fluid retention from fludrocortisone may also offset the NSAID's benefit in patients with hypertension or edema.
How serious is the interaction between Fludrocortisone and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salsalate dose and consider gastroprotection in high-risk patients. Monitor blood pressure, edema and signs of GI bleeding.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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