Drug interactions
Fludrocortisone + Somatrem
Severity: Minor
Fludrocortisone and Somatrem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids can blunt the growth-promoting action of growth hormone. Fludrocortisone has predominantly mineralocorticoid activity, so the effect at replacement doses is likely small.
What this interaction means in plain words
Fludrocortisone and Somatrem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism of growth hormone effects by glucocorticoid activity.
What to do
Monitor growth velocity in children; if glucocorticoids are also given, use the lowest effective dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Somatrem?
MediHelp rates the interaction as minor. Fludrocortisone and Somatrem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucocorticoids can blunt the growth-promoting action of growth hormone. Fludrocortisone has predominantly mineralocorticoid activity, so the effect at replacement doses is likely small.
How serious is the interaction between Fludrocortisone and Somatrem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth velocity in children; if glucocorticoids are also given, use the lowest effective dose.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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