Drug interactions
Fludrocortisone + Somatropin
Severity: Minor
Fludrocortisone and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is mainly a mineralocorticoid at usual doses, so its antagonism of growth hormone is likely small. Growth hormone can, however, change cortisol activation and affect glucocorticoid replacement in hypopituitary patients.
What this interaction means in plain words
Fludrocortisone and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD-1, and glucocorticoid activity may oppose growth hormone effects.
What to do
No dose change is usually needed; monitor growth in children and review adrenal replacement after starting somatropin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Somatropin?
MediHelp rates the interaction as minor. Fludrocortisone and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone is mainly a mineralocorticoid at usual doses, so its antagonism of growth hormone is likely small. Growth hormone can, however, change cortisol activation and affect glucocorticoid replacement in hypopituitary patients.
How serious is the interaction between Fludrocortisone and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor growth in children and review adrenal replacement after starting somatropin.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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