Drug interactions
Fludrocortisone + Theophylline
Severity: Minor
Fludrocortisone and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clinically meaningful pharmacokinetic interaction is established between fludrocortisone and theophylline. Fludrocortisone is a mineralocorticoid given at low doses, and it can cause hypokalemia, which may add to the arrhythmia risk seen with theophylline.
What this interaction means in plain words
Fludrocortisone and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Theophylline belongs to Respiratory.
Why it happens
No established metabolic interaction; additive hypokalemia is possible through mineralocorticoid effect plus theophylline-related potassium shifts.
What to do
Monitor serum potassium in patients on both drugs, particularly with higher fludrocortisone doses. No theophylline dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Theophylline?
MediHelp rates the interaction as minor. Fludrocortisone and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clinically meaningful pharmacokinetic interaction is established between fludrocortisone and theophylline. Fludrocortisone is a mineralocorticoid given at low doses, and it can cause hypokalemia, which may add to the arrhythmia risk seen with theophylline.
How serious is the interaction between Fludrocortisone and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on both drugs, particularly with higher fludrocortisone doses. No theophylline dose change is routinely needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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