Drug interactions
Fludrocortisone + Tofacitinib
Severity: Minor
Fludrocortisone and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is a corticosteroid used mainly for its mineralocorticoid effect, with minimal immunosuppressive activity at usual doses. Clinically meaningful additive immunosuppression with tofacitinib is unlikely at replacement doses.
What this interaction means in plain words
Fludrocortisone and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Tofacitinib belongs to Musculoskeletal.
Why it happens
Theoretical additive immunosuppression from the glucocorticoid activity, which is weak at usual doses.
What to do
No dose change is usually needed; remain aware of infection risk, particularly if higher doses are used or other steroids are co-prescribed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Tofacitinib?
MediHelp rates the interaction as minor. Fludrocortisone and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone is a corticosteroid used mainly for its mineralocorticoid effect, with minimal immunosuppressive activity at usual doses. Clinically meaningful additive immunosuppression with tofacitinib is unlikely at replacement doses.
How serious is the interaction between Fludrocortisone and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; remain aware of infection risk, particularly if higher doses are used or other steroids are co-prescribed.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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