Drug interactions
Fludrocortisone + Typhoid vaccine live
Severity: Moderate
Fludrocortisone and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine contains attenuated Salmonella Typhi, which may cause infection in immunosuppressed patients, and corticosteroids may also reduce the vaccine response. The risk is lower with replacement-dose fludrocortisone, but rises with glucocorticoid co-therapy.
What this interaction means in plain words
Fludrocortisone and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid immunosuppression reduces vaccine response and may permit greater replication of live attenuated bacteria.
What to do
Where immunosuppressive corticosteroid doses are in use, choose the inactivated Vi polysaccharide vaccine instead. For replacement-dose fludrocortisone alone, vaccination can usually proceed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Fludrocortisone and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral typhoid vaccine contains attenuated Salmonella Typhi, which may cause infection in immunosuppressed patients, and corticosteroids may also reduce the vaccine response. The risk is lower with replacement-dose fludrocortisone, but rises with glucocorticoid co-therapy.
How serious is the interaction between Fludrocortisone and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where immunosuppressive corticosteroid doses are in use, choose the inactivated Vi polysaccharide vaccine instead. For replacement-dose fludrocortisone alone, vaccination can usually proceed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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