Drug interactions
Fludrocortisone + Varicella virus vaccine live
Severity: Moderate
Fludrocortisone and Varicella virus vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live varicella vaccine can cause disseminated vaccine-strain infection in immunosuppressed patients, and corticosteroids also reduce the immune response. With replacement-dose fludrocortisone the risk is small, but it increases with concurrent glucocorticoid exposure.
What this interaction means in plain words
Fludrocortisone and Varicella virus vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid immunosuppression impairs control of live attenuated varicella virus and reduces vaccine immunogenicity.
What to do
Review total corticosteroid exposure. Defer vaccination if the patient receives immunosuppressive doses, following local immunization guidance on the interval after stopping therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Varicella virus vaccine live?
MediHelp rates the interaction as moderate. Fludrocortisone and Varicella virus vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live varicella vaccine can cause disseminated vaccine-strain infection in immunosuppressed patients, and corticosteroids also reduce the immune response. With replacement-dose fludrocortisone the risk is small, but it increases with concurrent glucocorticoid exposure.
How serious is the interaction between Fludrocortisone and Varicella virus vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review total corticosteroid exposure. Defer vaccination if the patient receives immunosuppressive doses, following local immunization guidance on the interval after stopping therapy.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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