Drug interactions
Fludrocortisone + Xipamide
Severity: Moderate
Fludrocortisone and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic that causes potassium loss, and fludrocortisone increases renal potassium excretion. Together they raise the risk of hypokalemia, which may cause arrhythmias and muscle weakness.
What this interaction means in plain words
Fludrocortisone and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from mineralocorticoid activity and distal tubular diuretic effect.
What to do
Monitor serum potassium and magnesium regularly and supplement or add a potassium-sparing agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Xipamide?
MediHelp rates the interaction as moderate. Fludrocortisone and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic that causes potassium loss, and fludrocortisone increases renal potassium excretion. Together they raise the risk of hypokalemia, which may cause arrhythmias and muscle weakness.
How serious is the interaction between Fludrocortisone and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and supplement or add a potassium-sparing agent if needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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