Drug interactions
Fluorouracil + Givinostat
Severity: Moderate
Fluorouracil and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QTc interval, and fluorouracil has been associated with QT prolongation and rarely arrhythmias or coronary vasospasm. Combined use may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Fluorouracil and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluorouracil belongs to Oncology; Givinostat belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization and QT prolongation.
What to do
Obtain a baseline ECG and repeat during concomitant use, and correct potassium and magnesium. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluorouracil
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Fluorouracil with Givinostat?
MediHelp rates the interaction as moderate. Fluorouracil and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QTc interval, and fluorouracil has been associated with QT prolongation and rarely arrhythmias or coronary vasospasm. Combined use may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Fluorouracil and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat during concomitant use, and correct potassium and magnesium. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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