Drug interactions
Fluorouracil + Glyburide-metformin
Severity: Moderate
Fluorouracil and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil may reduce CYP2C9-mediated clearance of glyburide, potentially increasing its glucose-lowering effect. Chemotherapy-related nausea, reduced intake and organ dysfunction can further raise hypoglycemia risk.
What this interaction means in plain words
Fluorouracil and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluorouracil belongs to Oncology; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible inhibition of CYP2C9 metabolism of glyburide; evidence is limited.
What to do
Monitor blood glucose frequently during chemotherapy cycles and adjust glyburide dose as needed. Also monitor renal function and hydration status because of metformin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Fluorouracil
Frequently asked questions
Can I take Fluorouracil with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fluorouracil and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil may reduce CYP2C9-mediated clearance of glyburide, potentially increasing its glucose-lowering effect. Chemotherapy-related nausea, reduced intake and organ dysfunction can further raise hypoglycemia risk.
How serious is the interaction between Fluorouracil and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during chemotherapy cycles and adjust glyburide dose as needed. Also monitor renal function and hydration status because of metformin.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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