Drug interactions
Fluoxymesterone + Gliclazide
Severity: Moderate
Fluoxymesterone and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anabolic androgenic steroids such as fluoxymesterone can improve insulin sensitivity and lower blood glucose, which may enhance the effect of gliclazide. This increases the chance of hypoglycaemia.
What this interaction means in plain words
Fluoxymesterone and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgens may increase insulin sensitivity and alter glucose metabolism, adding to the sulfonylurea effect.
What to do
Monitor blood glucose when starting or stopping the androgen and reduce the gliclazide dose if hypoglycaemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Fluoxymesterone with Gliclazide?
MediHelp rates the interaction as moderate. Fluoxymesterone and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anabolic androgenic steroids such as fluoxymesterone can improve insulin sensitivity and lower blood glucose, which may enhance the effect of gliclazide. This increases the chance of hypoglycaemia.
How serious is the interaction between Fluoxymesterone and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the androgen and reduce the gliclazide dose if hypoglycaemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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