Drug interactions
Fluoxymesterone + Glipizide-metformin
Severity: Moderate
Fluoxymesterone and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anabolic androgenic steroids can enhance insulin sensitivity and lower blood glucose, which may increase hypoglycemia risk with glipizide. Metformin alone carries little hypoglycemia risk, so the concern is mainly from the sulfonylurea component.
What this interaction means in plain words
Fluoxymesterone and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgens alter insulin sensitivity and glucose metabolism, producing additive glucose-lowering effects with the sulfonylurea.
What to do
Monitor blood glucose when starting or stopping the androgen and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Fluoxymesterone with Glipizide-metformin?
MediHelp rates the interaction as moderate. Fluoxymesterone and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anabolic androgenic steroids can enhance insulin sensitivity and lower blood glucose, which may increase hypoglycemia risk with glipizide. Metformin alone carries little hypoglycemia risk, so the concern is mainly from the sulfonylurea component.
How serious is the interaction between Fluoxymesterone and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the androgen and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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