Drug interactions
Fluoxymesterone + Glyburide-metformin
Severity: Moderate
Fluoxymesterone and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgenic anabolic steroids such as fluoxymesterone may improve insulin sensitivity and lower blood glucose, which could add to the effect of glyburide and metformin. Hypoglycemia is possible, mainly from the sulfonylurea component.
What this interaction means in plain words
Fluoxymesterone and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering effect, likely through altered insulin sensitivity caused by androgens.
What to do
Monitor blood glucose when starting or stopping fluoxymesterone. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Fluoxymesterone with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fluoxymesterone and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgenic anabolic steroids such as fluoxymesterone may improve insulin sensitivity and lower blood glucose, which could add to the effect of glyburide and metformin. Hypoglycemia is possible, mainly from the sulfonylurea component.
How serious is the interaction between Fluoxymesterone and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluoxymesterone. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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