Drug interactions
Fluoxymesterone + Repaglinide
Severity: Moderate
Fluoxymesterone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens such as fluoxymesterone may lower blood glucose and increase insulin sensitivity, which could potentiate repaglinide. Hypoglycemia is possible, particularly at the start of therapy.
What this interaction means in plain words
Fluoxymesterone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgen-related improvement in insulin sensitivity and glucose lowering adds to repaglinide.
What to do
Monitor blood glucose when fluoxymesterone is started or stopped and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Fluoxymesterone with Repaglinide?
MediHelp rates the interaction as moderate. Fluoxymesterone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens such as fluoxymesterone may lower blood glucose and increase insulin sensitivity, which could potentiate repaglinide. Hypoglycemia is possible, particularly at the start of therapy.
How serious is the interaction between Fluoxymesterone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluoxymesterone is started or stopped and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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