Drug interactions
Flurazepam + Lorazepam
Severity: Moderate
Flurazepam and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so combined use gives additive sedation and respiratory depression. Flurazepam has long-acting active metabolites, so effects may persist and accumulate, especially in older adults.
What this interaction means in plain words
Flurazepam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Avoid concurrent use of two benzodiazepines; if unavoidable, use the lowest doses and monitor for daytime sedation, confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Flurazepam with Lorazepam?
MediHelp rates the interaction as moderate. Flurazepam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so combined use gives additive sedation and respiratory depression. Flurazepam has long-acting active metabolites, so effects may persist and accumulate, especially in older adults.
How serious is the interaction between Flurazepam and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines; if unavoidable, use the lowest doses and monitor for daytime sedation, confusion and falls.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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