Drug interactions
Flurazepam + Lorlatinib
Severity: Minor
Flurazepam and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce concentrations of flurazepam and its active metabolites, weakening hypnotic effect.
What this interaction means in plain words
Flurazepam and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lorlatinib induces CYP3A4, increasing flurazepam metabolism.
What to do
Monitor sleep response and adjust the dose if effect is inadequate. No routine action is otherwise needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Flurazepam with Lorlatinib?
MediHelp rates the interaction as minor. Flurazepam and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib may reduce concentrations of flurazepam and its active metabolites, weakening hypnotic effect.
How serious is the interaction between Flurazepam and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sleep response and adjust the dose if effect is inadequate. No routine action is otherwise needed.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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