Drug interactions
Flurazepam + Morphine
Severity: Major
Flurazepam and Morphine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining opioids with benzodiazepines can cause profound sedation, respiratory depression, coma and death. The long-acting active metabolites of flurazepam prolong this risk.
What this interaction means in plain words
Flurazepam and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptors and GABA-A potentiation.
What to do
Avoid combining unless alternatives are inadequate; use the lowest doses for the shortest duration and monitor sedation and respiration closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Flurazepam with Morphine?
MediHelp rates the interaction as major. Flurazepam and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining opioids with benzodiazepines can cause profound sedation, respiratory depression, coma and death. The long-acting active metabolites of flurazepam prolong this risk.
How serious is the interaction between Flurazepam and Morphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless alternatives are inadequate; use the lowest doses for the shortest duration and monitor sedation and respiration closely.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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