Drug interactions
Flurazepam + Oxazepam
Severity: Moderate
Flurazepam and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of two benzodiazepines is duplicate therapy and increases sedation, impaired coordination and respiratory depression. Flurazepam has long-acting active metabolites, so effects can accumulate, particularly in older adults.
What this interaction means in plain words
Flurazepam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation by two benzodiazepines.
What to do
Avoid combining the two and use a single benzodiazepine at the lowest effective dose. If both are temporarily needed, monitor for daytime sedation, falls and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flurazepam and Oxazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Flurazepam with Oxazepam?
MediHelp rates the interaction as moderate. Flurazepam and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of two benzodiazepines is duplicate therapy and increases sedation, impaired coordination and respiratory depression. Flurazepam has long-acting active metabolites, so effects can accumulate, particularly in older adults.
How serious is the interaction between Flurazepam and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two and use a single benzodiazepine at the lowest effective dose. If both are temporarily needed, monitor for daytime sedation, falls and respiratory depression.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
