Drug interactions
Flurbiprofen + Glibenclamide
Severity: Moderate
Flurbiprofen and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may potentiate the hypoglycemic action of glyburide. Both are CYP2C9 substrates and highly protein bound, so exposure to free glyburide may rise. Clinically significant hypoglycemia is uncommon but possible, especially in older patients or those with renal impairment.
What this interaction means in plain words
Flurbiprofen and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Glibenclamide belongs to Endocrine.
Why it happens
Competition for CYP2C9 metabolism and displacement from plasma protein binding sites may raise free glyburide levels.
What to do
Monitor blood glucose closely when flurbiprofen is added or withdrawn and educate the patient about hypoglycemia. Lower the glyburide dose if glucose falls, or choose a non-NSAID analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Flurbiprofen with Glibenclamide?
MediHelp rates the interaction as moderate. Flurbiprofen and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen may potentiate the hypoglycemic action of glyburide. Both are CYP2C9 substrates and highly protein bound, so exposure to free glyburide may rise. Clinically significant hypoglycemia is uncommon but possible, especially in older patients or those with renal impairment.
How serious is the interaction between Flurbiprofen and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when flurbiprofen is added or withdrawn and educate the patient about hypoglycemia. Lower the glyburide dose if glucose falls, or choose a non-NSAID analgesic such as paracetamol.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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